Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression.

Jodi L PawluskiUrsula BrainGeoffrey L HammondTim F Oberlander

Published in: Archives of women's mental health (2018)

The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.

Keyphrases

pregnant women
pregnancy outcomes
binding protein
stress induced
depressive symptoms
sleep quality
preterm infants
polycystic ovary syndrome
preterm birth
gestational age
birth weight
mass spectrometry
skeletal muscle
atomic force microscopy
physical activity
newly diagnosed