The subtleties of cognitive decline in multiple sclerosis: an exploratory study using hierarchichal cluster analysis of CANTAB results.

Hideraldo Luis Souza CabeçaLuciano Chaves RochaAmanda Ferreira SabbáAlessandra Mendonça TomásNatali Valim Oliver Bento-TorresDaniel Clive AnthonyCristovam Wanderley Picanço Diniz

Published in: BMC neurology (2018)

We suggest that the use of selected large-scale automated visuospatial tests from the CANTAB in combination with multivariate statistical analyses may reveal subtle and earlier changes in information processing speed and cognition. This may expand our ability to define the limits between normal and impaired cognition in patients with Multiple Sclerosis.

Keyphrases

cognitive decline
mild cognitive impairment
multiple sclerosis
white matter
working memory
machine learning
deep learning
high throughput
single cell
genome wide
health information
data analysis
healthcare
gene expression