Factors Influencing the Efficacy of Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury.

Elisha PurcellTimothy NguyenMadeleine SmithTayla PennyMadison C B PatonLindsay ZhouGraham JenkinSuzanne L MillerCourtney A McDonaldAtul Malhotra

Published in: Stem cells translational medicine (2023)

Preclinical evidence suggests UCBCs to show greater efficacy in the injury model of IVH compared to HI, the use of UCB-MSCs compared to UCB-MNCs and the use of local administrative routes compared to systemic routes in animal models of perinatal brain injury. Further research is needed to improve certainty of evidence and address knowledge gaps.

Keyphrases

brain injury
cell therapy
mesenchymal stem cells
umbilical cord
subarachnoid hemorrhage
cerebral ischemia
healthcare
stem cells
bone marrow