Smoking and vaping alter genes related to mechanisms of SARS-CoV-2 susceptibility and severity: a systematic review and meta-analysis.
Rachel BowsherTimothy H MarczyloKaren GoochAlexis BaileyMatthew D WrightEmma L MarczyloPublished in: The European respiratory journal (2024)
Exposure to tobacco cigarettes, e-cigarettes or nicotine may therefore impact initial host-pathogen interactions and disease severity. Smokers and vapers of e-cigarettes with nicotine could potentially be at increased risk of SARS-CoV-2 infection, associated cytokine storm, and acute respiratory distress syndrome. However, further research is required, particularly on e-cigarettes, to determine the biological mechanisms involved in perturbation of viral-entry genes and host-pathogen interactions and subsequent responses within the respiratory tract. This will improve our physiological understanding of the impact of smoking and vaping on COVID-19, informing public health advice and providing improved guidance for management of SARS-CoV-2 and other respiratory viruses.
Keyphrases
- smoking cessation
- sars cov
- acute respiratory distress syndrome
- respiratory tract
- respiratory syndrome coronavirus
- public health
- replacement therapy
- extracorporeal membrane oxygenation
- genome wide
- mechanical ventilation
- candida albicans
- coronavirus disease
- bioinformatics analysis
- genome wide identification
- genome wide analysis
- drug induced