mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?

Nadia VazirpanahAndrea OttriaMaarten van der LindenCatharina G K WichersMark SchuivelingEllen van LochemAmanda Phipps-GreenTony MerrimanMaili ZimmermannMatthijs JansenTimothy R D J RadstakeJasper C A Broen

Published in: Annals of the rheumatic diseases (2019)

We propose mTOR inhibition as a novel therapeutic target of interest in gout treatment.

Keyphrases

cell death
uric acid
cell proliferation
oxidative stress
diabetic rats
high glucose
drug induced
stem cells
combination therapy
replacement therapy
pi k akt