Pathogenicity and virulence of hepatitis A virus.
Rosa M PintóFrancisco-Javier Pérez-RodríguezMaria-Isabel CostafredaGemma Chavarria-MiróSusana GuixEnric RibesAlbert BoschPublished in: Virulence (2021)
Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form. The reason for these different outcomes is unknown, but it is generally accepted that host factors such as the immunological status, age and the occurrence of underlaying hepatic diseases are the main determinants of the severity. However, it cannot be ruled out that some virus traits may also contribute to the severe clinical outcomes. In this review, we will analyze which genetic determinants of the virus may determine virulence, in the context of a paradigmatic virus in terms of its genomic, molecular, replicative, and evolutionary features.
Keyphrases
- escherichia coli
- pseudomonas aeruginosa
- genome wide
- liver failure
- end stage renal disease
- staphylococcus aureus
- newly diagnosed
- acute lymphoblastic leukemia
- chronic kidney disease
- risk assessment
- ejection fraction
- gene expression
- acute myeloid leukemia
- disease virus
- peritoneal dialysis
- type diabetes
- hepatitis b virus
- skeletal muscle
- aortic dissection
- patient reported