Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms.
Marcelo A StrauchMarcelo Amorim TomazMarcos Monteiro-MachadoBruno Lemos ConsFernando Chagas Patrão-NetoJhonatha da Mota Teixeira-CruzMatheus da Silva Tavares-HenriquesPâmella Dourila Nogueira-SouzaSara L S GomesPaulo R R CostaEdgar SchaefferAlcides J M da SilvaPaulo A MeloPublished in: PloS one (2019)
This research using a natural quinone and some related synthetic quinone compounds has shown that they exhibit antivenom activity; especially the compound 3a. The data from 3a showed a decrease in inflammatory venom effects, presumably those that are metalloproteinase-derived. Its ability to counteract such snake venom activities contributes to the search for improving the management of venomous snakebites.