Extent of radiological response does not reflect survival in primary central nervous system lymphoma.
Matthijs van der MeulenAlida A PostmaMarion SmitsKaterina BakuninaMonique C MinnemaTatjana SeuteGavin CullRoelien H EntingMarjolein van der PoelWendy B C StevensDieta BrandsmaAart BeekerJeanette K DoorduijnSamar IssaMartin J Van Den BentJacoline E C BrombergPublished in: Neuro-oncology advances (2021)
Reliability of response assessment (CR/CRu/PR) is moderate even by central radiology review and these response categories do not reliably predict survival. Therefore, primary outcome in PCNSL studies should be survival rather than CR or CR/CRu-rate.