Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling.

Fang WeiJian SongCui ZhangJun LinRong XueLi-Dong ShanShan GongGuo-Xing ZhangZheng-Hong QinGuang-Yin XuLin-Hui Wang

Published in: Psychopharmacology (2019)

Chronic stress could impair the AQP4-mediated glymphatic transport in the brain through glucocorticoid signaling. Our results also suggest that GR antagonist could be beneficial to rescue the glymphatic function suppressed by chronic stress.

Keyphrases

stress induced
drug induced
resting state
cerebral ischemia
subarachnoid hemorrhage