Antifungal activity and toxicological parameters of 8-hydroxyquinoline-5-sulfonamides using alternative animal models.

Bruna PippiA R JoaquimS MerkelR A ZanetteM E M NunesD G da Costa SilvaL E SchimithMário Lettieri TeixeiraJ L FrancoSaulo Fernandes de AndradeA M Fuentefria

Published in: Journal of applied microbiology (2020)

The increased incidence of Candida infections resistant to antifungals currently available requires acceleration of the discovery of new agents with properties of inhibiting this fungal pathogen. In this study, we have described the antifungal potential and toxicity of two 8-hydroxyquinoline derivatives using in vivo alternative models, and the results confirm their potential to be developed as new drug candidates.

Keyphrases

candida albicans
small molecule
risk factors
signaling pathway
oxidative stress
emergency department
high throughput
cystic fibrosis
pseudomonas aeruginosa
climate change
single cell