In situ Photoactivated Antibacterial and Antioxidant Composite Materials to Promote Bone Repair.

Trauma and tumor removal usually cause bone defects; in addition, the related postoperative infection also should be carefully considered in clinical. In this study, we first prepared polylactic acid (PLLA) composite fibers containing CeO 2 by electrospinning technology. Then, the PLLA/ CeO 2 @PDA /Ag composite materials were successfully prepared by reducing Ag + to AgNPs coating in situ and binding AgNPs to the materials surface by mussel structure-liked polydopamine (PDA). In the materials, Ag + can be slowly released in simulated body fluids. Based on the photothermal performance of AgNPs, the photothermal conversion efficiency of the materials were 21%, under NIR 808 nm illumination. The effective photothermal conversion can help materials fighting with E. coli and S. aureus in 3 hours, with an antibacterial rate of 100%. Additionally, the sustained Ag + release contribute to the antibacterial in long term. Meanwhile, the materials can mimic the bio-behavior of superoxide dismutase (SOD) and catalase (CAT) in decreasing the singlet oxygen level and removing the excess reactive oxygen species (ROS). Furthermore, the materials were beneficial for cell proliferation and osteogenic differentiation in vitro. In this study, we successfully constructed a promising bone-regenerated material with high photothermal conversion efficiency and antibacterial and anti-oxidation properties. This article is protected by copyright. All rights reserved.