Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.
Omar MessaoudiEnge SudarmanMourad BendahouRolf JansenMarc StadlerJoachim WinkPublished in: Journal of natural products (2019)
In our screening program for new biologically active secondary metabolites, a new strain, Nocardiopsis CG3 (DSM 106572), isolated from the saltpan of Kenadsa, was found to produce five new polyene macrolactams, the kenalactams A-E (1-5). Their structures were elucidated by spectral methods (NMR and HRESIMS), and the absolute configuration was derived by chemical derivatization (Mosher's method). Through a feeding experiment, alanine was proven to be the nitrogen-bearing starter unit involved in biosynthesis of the polyketide kenalactam A (1). Kenalactam E (5) was cytotoxic against human prostate cancer PC-3 cells with an IC50 value of 2.1 μM.
Keyphrases
- prostate cancer
- ms ms
- high resolution
- endothelial cells
- radical prostatectomy
- magnetic resonance
- optical coherence tomography
- quality improvement
- liquid chromatography tandem mass spectrometry
- induced pluripotent stem cells
- high performance liquid chromatography
- simultaneous determination
- solid state
- liquid chromatography
- tandem mass spectrometry
- magnetic resonance imaging
- gas chromatography
- computed tomography
- solid phase extraction
- ultra high performance liquid chromatography
- contrast enhanced