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Iron overload causes macrophages to produce a pro-inflammatory phenotype in the synovium of hemophiliac arthritis via the acetyl-p53 pathway.

Nanyu PangMingyang DingHu YangQigang ZhongLiujie ZhengDasheng LuoYunfeng Yao
Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2023)
Synovial iron overload is associated with changes in P53 acetylation in hemophiliac arthritis (HA). Acetylated p53, a known regulator of macrophage polarization, is highly expressed in HA synovium, suggesting a potential role in M1 polarization. HA synovial macrophages predominantly polarize into the pro-inflammatory M1 phenotype, secreting elevated levels of pro-inflammatory cytokines.
Keyphrases
  • rheumatoid arthritis
  • iron deficiency
  • transcription factor
  • anti inflammatory
  • african american