Pathology and Monkeypox virus Localization in Tissues From Immunocompromised Patients With Severe or Fatal Mpox.
Jana M RitterRoosecelis B MartinesJulu BhatnagarAgam K RaoJulian A VillalbaLuciana Silva-FlanneryElizabeth LeeHannah A BullockChristina L HutsonTerra CederrothCynthia K HarrisKristin HordYa XuCameron A BrownJack P GuccioneMatthew MillerChristopher D PaddockSarah Reagan-Steinernull nullPublished in: The Journal of infectious diseases (2024)
Severe mpox in immunocompromised patients is characterized by extensive viral infection of tissues and viremic dissemination that can progress despite available therapeutics. Digestive tract and lung involvement are common and associated with prominent histopathological and clinical manifestations. Coinfections may complicate mpox diagnosis and treatment. Significant viral DNA (likely correlating to infectious virus) in tissues necessitates enhanced biosafety measures in healthcare and autopsy settings.
Keyphrases
- healthcare
- gene expression
- end stage renal disease
- chronic kidney disease
- early onset
- sars cov
- single molecule
- peritoneal dialysis
- respiratory failure
- cell free
- intensive care unit
- patient reported outcomes
- extracorporeal membrane oxygenation
- health insurance
- acute respiratory distress syndrome
- mechanical ventilation