Potential Protective Function of Adiponectin in Diabetic Retinopathy.
Hui DengMeichen AiYuchen CaoLiyang CaiXi GuoXiongyi YangGuoguo YiMin FuPublished in: Ophthalmology and therapy (2023)
Adiponectin, one of the most ubiquitous adipokines found in the blood, plays a major role in glucolipid metabolism and energy metabolism and regulation. In recent years, a growing body of research indicates that adiponectin also plays a significant role in diabetic retinopathy. In the present review, we specifically address the protective effects of adiponectin on the development and progression of diabetic retinopathy through improvement in insulin resistance, alleviation of oxidative stress, limiting of inflammation, and prevention of vascular remodeling, with the aim to explore new potential approaches and targets for the prevention and treatment of diabetic retinopathy.
Keyphrases
- diabetic retinopathy
- insulin resistance
- metabolic syndrome
- oxidative stress
- optical coherence tomography
- adipose tissue
- high fat diet
- skeletal muscle
- type diabetes
- polycystic ovary syndrome
- human health
- high fat diet induced
- ischemia reperfusion injury
- risk assessment
- combination therapy
- climate change
- signaling pathway
- replacement therapy