Total Synthesis of Kibdelomycin.
Chi HeYu WangCheng BiDavid S PetersTimothy J GallagherJohannes TeskeJason S ChenRachel CorsettiAnthony D'OnofrioKim LewisPhil S BaranPublished in: Angewandte Chemie (International ed. in English) (2022)
A modular total synthesis of kibdelomycin is disclosed that should enable structure-activity relationship (SAR) studies of this interesting class of antibiotics. The route uses simple building blocks and addresses lingering questions about its structural assignment and relationship to amycolamicin, a recently described natural product reported to have a similar structure. Initial antibacterial assays reveal that both C-22 epimers (the N-glycosidic linkage) of the natural product have similar activity while structurally truncated analogs lose activity.