Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy.
Marta CasarrubiosAlberto Cruz-BermúdezErnest NadalAmelia InsaMaría Del Rosario García CampeloMartín LázaroManuel DómineMargarita MajemDelvys Rodríguez-AbreuAlex Martinez-MartiJavier De Castro CarpeñoManuel CoboGuillermo López-VivancoElvira Del BarcoReyes Bernabé CaroNuria ViñolasIsidoro Barneto ArandaSantiago ViteriBartomeu MassutiMiguel BarquínRaquel Laza-BriviescaBelén Sierra-RoderoEdwin Roger Parra CuentesBeatriz Sanchez-EspiridionPedro RochaHumam KadaraIgnacio I WistubaAtocha RomeroVirginia CalvoMariano ProvencioPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We have identified two parameters derived from TCR repertoire analysis that could outperform PD-L1 TPS and TMB as predictive biomarkers of CPR after neoadjuvant chemoimmunotherapy, and unraveled possible mechanisms of CPR involving enhanced tumor immunogenicity and peripheral immunosurveillance.