The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer.

Lei ZhangYidong LiQianchao WangZhuo ChenXiaoyun LiZhuoxun WuChaohua HuDan LiaoWei ZhangZhe-Sheng Chen

Published in: Molecular cancer (2020)

The reversal of the dual functions of ABC-transporter-mediated and AKT-activation-enhanced MDR through the inhibition or knockout of PI3K 110α or 110β promises to improve current strategies based on combined drug treatments to overcome MDR challenges.

Keyphrases

multidrug resistant
papillary thyroid
signaling pathway
cell proliferation
squamous cell
human health
climate change
adverse drug
drug induced