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The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer.

Lei ZhangYidong LiQianchao WangZhuo ChenXiaoyun LiZhuoxun WuChaohua HuDan LiaoWei ZhangZhe-Sheng Chen
Published in: Molecular cancer (2020)
The reversal of the dual functions of ABC-transporter-mediated and AKT-activation-enhanced MDR through the inhibition or knockout of PI3K 110α or 110β promises to improve current strategies based on combined drug treatments to overcome MDR challenges.
Keyphrases
  • multidrug resistant
  • papillary thyroid
  • signaling pathway
  • cell proliferation
  • squamous cell
  • human health
  • climate change
  • adverse drug
  • drug induced