White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition.
Antoine Garnier-CrussardSalma BougachaMiranka WirthClaire AndréMarion DelarueBrigitte LandeauFlorence MézengeElizabeth KuhnJulie GonneaudAnne ChocatAnne QuillardEglantine Ferrand-DevougeVincent de La SayetteDenis VivienPierre Krolak-SalmonGaëlle ChételatPublished in: Alzheimer's research & therapy (2020)
WMH increased with age and were associated with worse executive functions across the adult lifespan and with worse working memory in young/middle-aged adults. Aβ load was weakly associated with WMH and did not change the relationship found between WMH and executive functions. This study argues for the clinical relevance of WMH across the adult lifespan, even in young and middle-aged adults with low WMH.