Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device.
Caitlin BurkeMatthew R DreherAyele H NegussieAndrew S MikhailPavel YarmolenkoAakash PatelBrenden SkilskyjBradford J WoodDieter HaemmerichPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2017)
The millifluidic device allows measurement of TSL release at unprecedented temporal resolution, thus allowing adequate characterisation of TSL release at time scales relevant for intravascular triggered drug release. The type of buffer and encapsulated compound significantly affect release kinetics and need to be considered when designing and evaluating novel TSL-drug combinations.