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Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer.

Cynthia WeigelMelissa A MaczisElisa N D PalladinoChristopher D GreenMichael MaceykaChunqing GuoXiang-Yang WangMikhail G DozmorovSheldon MilstienSarah Spiegel
Published in: Cancer research (2023)
Sphingosine kinase 2 (SphK2) facilitates the activation of stromal fibroblasts to tumor-promoting cancer-associated fibroblasts by suppressing host p53 activity, revealing SphK2 as a potential target to reprogram the TME.
Keyphrases
  • extracellular matrix
  • bone marrow
  • protein kinase
  • tyrosine kinase
  • risk assessment
  • human health
  • breast cancer risk