Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer.

Cynthia Weigel Melissa A Maczis Elisa N D Palladino Christopher D Green Michael Maceyka Chunqing Guo Xiang-Yang Wang Mikhail G Dozmorov Sheldon Milstien Sarah Spiegel

Published in: Cancer research (2023)

Sphingosine kinase 2 (SphK2) facilitates the activation of stromal fibroblasts to tumor-promoting cancer-associated fibroblasts by suppressing host p53 activity, revealing SphK2 as a potential target to reprogram the TME.

Keyphrases

extracellular matrix
bone marrow
protein kinase
tyrosine kinase
risk assessment
human health
breast cancer risk