Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study.

Ya-Sian ChangChien-Yu LinTing-Yuan LiuChung-Ming HuangChin-Chun ChungYu-Chia ChenFuu-Jen TsaiJan-Gowth ChangShun-Jen Chang

Published in: Arthritis research & therapy (2022)

We found new variants on chromosome 1 significantly relating to gout, and PRS predicts the risk of developing gout/AH more robustly based on the SNPs' effect types on the trait.

Keyphrases

copy number
uric acid
genome wide association study
genome wide
dna methylation
metabolic syndrome
gene expression