BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.

M GraffK E NorthA S RichardsonK L YoungA L MazulH M HighlandK L MohlkeL A LangeE M LangeK Mullan HarrisPenny Gordon-Larsen

Published in: International journal of obesity (2005) (2016)

The observed association between variants in/near FTO, MC4R, MTCH2, TFAP2B, SEC16B and TMEM18 with change in BMI from adolescence to young adulthood suggest that the genetic effect of BMI loci varies over time in a complex manner, highlighting the importance of investigating loci influencing obesity risk across the life course.

Keyphrases

body mass index
genome wide
weight gain
depressive symptoms
genome wide association study
copy number
genome wide association
metabolic syndrome
dna methylation
insulin resistance
type diabetes
weight loss
middle aged
early life
gene expression
physical activity
adipose tissue