Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice.
Julia Barbara Kral-PointnerPatrick HaiderPetra L SzaboManuel SalzmannMira BrekaloKarl Heinrich SchneiderWaltraud Cornelia SchrottmaierChristoph KaunSonja BleichertAttila KissRomana SickhaChristian HengstenbergKurt HuberChristine BrostjanHelga BergmeisterAlice AssingerBruno Karl PodesserJohann WojtaPhilipp J HohensinnerPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Inhibition of P-selectin-dependent activation of monocytes and neutrophils accelerates venous thrombosis resolution due to reduced infiltration and activation of innate immune cells at the site of thrombus formation, which prevents early thrombus stabilization and facilitates fibrinolysis.