Comparative in vitro treatment of mesenchymal stromal cells with GDF-5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy.
Manuel WeißenbergerMike WagenbrennerJoachim NickelRasmus AhlbrechtTorsten BlunkAndre F SteinertFabian GilbertPublished in: Journal of experimental orthopaedics (2023)
R57A is a stronger inducer of chondrogenesis in BMSCs than the GDF-5 wild type while leading to lower levels of chondrogenic hypertrophy in comparison with TGF-ß1.