The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study.
Lay-Kim TanChun Lai TooLina Marcela Diaz-GalloSulaiman WahinuddinIng Soo LauHussein HeselynnShahril Nor-ShuhailaSuk Chyn GunMageswaran EashwaryMohamed Said Mohd-ShahrirMohd Mokhtar AinonRosman AzmillahOthman MuhainiMurad ShahnazLars AlfredssonLars KlareskogLeonid PadyukovPublished in: Arthritis research & therapy (2021)
Our results demonstrate that the RA-associated genetic factors in the multi-ethnic Malaysian population are similar to those in the Caucasian population, despite significant differences in the genetic architecture of HLA region across populations. A novel and distinct independent association between the HLA-DQB1*03:02 allele and ACPA-positive RA was observed in the Malays. In common with the Caucasian population, there is little risk from HLA region for ACPA-negative RA.