Widespread Associations between Behavioral Metrics and Brain Microstructure in ASD.

This study establishes numerous relationships between multiple behavioral, language, and social metrics in ASD. Subsequently, this study is the first to then show associations between diffusion microstructure and subscales of behavioral assessments. Limited associations of these behaviors with conduction velocity may indicate that axonal diameter is a predominating factor in characterizing ASD over other metrics, such as myelination, however within ASD subjects the g-ratio is more closely related to behavioral metrics, suggesting a potential role for myelination in ASD severity. These findings suggest that some subscales and metrics more accurately capture behaviors associated neurologically with ASD than others, including composite scores, demonstrating the potential to identify children at high risk for ASD at an earlier age.