Acute and chronic neuroinflammation is triggered by diabetic ketoacidosis in a rat model.
Nicole S GlaserSteven ChuBenjamin HungLuis FernandezHeike WulffDaniel TancrediMartha E ODonnellPublished in: BMJ open diabetes research & care (2021)
These data confirm that DKA causes acute systemic inflammation and neuroinflammation in a rat model. Importantly, the neuroinflammatory response triggered by DKA is long-lasting, suggesting the possibility that DKA-induced chronic neuroinflammation could contribute to long-term cognitive decline in individuals with diabetes.
Keyphrases
- cognitive decline
- drug induced
- liver failure
- lipopolysaccharide induced
- traumatic brain injury
- lps induced
- mild cognitive impairment
- type diabetes
- respiratory failure
- cognitive impairment
- cerebral ischemia
- aortic dissection
- cardiovascular disease
- inflammatory response
- electronic health record
- high glucose
- hepatitis b virus
- intensive care unit
- big data
- glycemic control
- artificial intelligence
- endothelial cells
- subarachnoid hemorrhage
- brain injury