Methods for anti-factor VIII antibody levels in haemophilia A patients - validation of a multiplex immunoassay and comparability with assays measuring non-neutralising and neutralising antibodies (inhibitors).
Myriam MartinCecilia AugustssonVivian LindRiam Al-SabtiMy Chi LamNadine G AnderssonKarin StrandbergPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2022)
The anti-FVIII antibody xFLI method is adaptable to clinical practice and more sensitive and reproducible than ELISA and CBA. Actual NNA titers are determined to both full-length and B-domain deleted FVIII. The xFLI is thus valuable for confirmation of all anti-FVIII antibodies.