Universal Digital High Resolution Melt for the detection of pulmonary mold infections.
Tyler GoshiaApril AralarNathan P WiederholdJeffrey D JenksSanjay R MehtaMridu SinhaAprajita KarmakarAnkit SharmaRachit ShrivastavaHaoxiang SunPhilip Lewis WhiteMartin HoeniglStephanie I FraleyPublished in: bioRxiv : the preprint server for biology (2023)
U-dHRM showed promising performance as a separate or combination diagnostic approach to standard mycological tests. The speed of U-dHRM and its ability to simultaneously identify and quantify clinically relevant mold pathogens in polymicrobial samples as well as detect emerging opportunistic pathogens may provide information that could aid in treatment decisions and improve patient outcomes.