Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities.
Han LuoWei QinHong ZhangFu-Cai RenWen-Tao FangQing-Hua KongLiu YangJian-Mei ZhangCheng-Wu FangJiang-Miao HuShou-Jin LiuPublished in: Molecules (Basel, Switzerland) (2022)
The present study aimed to identify the composition of the aerial parts of Rubia cordifolia L. A chemical investigation on the EtOAc extracts from the aerial parts of Rubia cordifolia resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D ( 1 - 4 ), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1 , 3 and 10 exhibited significant inhibitory activities with IC 50 values of 14.05, 23.48 and 29.23 μmol·L -1 , respectively. Their antibacterial activities of four bacteria, Escherichia coli (ATCC 25922), Staphylococcus aureus subsp. aureus (ATCC 29213), Salmonella enterica subsp. enterica (ATCC 14028) and Pseudomonas aeruginosa (ATCC 27853), were also evaluated. Our results indicated that the antibacterial activity of these compounds is inactive.
Keyphrases
- pseudomonas aeruginosa
- staphylococcus aureus
- escherichia coli
- silver nanoparticles
- biofilm formation
- high resolution
- induced apoptosis
- anti inflammatory
- cystic fibrosis
- adipose tissue
- cell cycle arrest
- inflammatory response
- electronic health record
- acinetobacter baumannii
- cell death
- wound healing
- drug resistant
- cell proliferation
- methicillin resistant staphylococcus aureus
- deep learning