Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain-derived neurotrophic factor exon I promoter in the adult rat hippocampus.
Sung Woo ParkMi Kyoung SeoJung Goo LeeLe Thi HienYoung Hoon KimPublished in: Psychiatry and clinical neurosciences (2017)
These findings indicate that MS induced epigenetic changes at the BDNF exon I promoter and these changes were prevented by antidepressant drug treatment during adulthood.
Keyphrases
- dna methylation
- major depressive disorder
- gene expression
- drug induced
- transcription factor
- mass spectrometry
- multiple sclerosis
- high glucose
- oxidative stress
- diabetic rats
- ms ms
- adverse drug
- depressive symptoms
- liquid chromatography
- bipolar disorder
- body mass index
- pregnant women
- replacement therapy
- prefrontal cortex