Pharmacokinetics and Target Attainment of Antimicrobial Drugs Throughout Pregnancy: Part I-Penicillins.
M R HesseJ R PrinsM N Lub-de HoogeH L J WinterJ G W KosterinkD J TouwPaola MianPublished in: Clinical pharmacokinetics (2023)
The larger Vd and higher CL in second and third trimester pregnant women might warrant a higher dosage or shortening of the dosing interval of penicillins to increase target attainment. Studies frequently fail to provide dosing advice for pregnant women, even if the necessary PK information was available.