Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice.

Liyang DongYing WangTingting ZhengYanan PuYongbin MaXin QiWenzhe ZhangFei XueZirui ShanJiameng LiuXuefeng WangChaoming Mao

Published in: Stem cell research & therapy (2021)

Our findings provided the first evidence that hypoxic hUCMSC-derived EVs attenuated allergic airway inflammation and airway remodeling in chronic asthma mice, potentially creating new avenues for the treatment of asthma.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance
wild type
combination therapy
skeletal muscle