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Severe disruption and disorganization of dermal collagen fibrils in early striae gravidarum.

Frank WangK CalderoneT T DoN R SmithY R HelfrichT R B JohnsonS KangJ J VoorheesG J Fisher
Published in: The British journal of dermatology (2018)
Early SG display marked separation of collagen bundles and emergence of disorganized collagen fibrils that fail to form bundles. These alterations may reflect ineffective repair of collagen bundles disrupted by intense skin stretching. Persistent disruption of the collagenous extracellular matrix likely promotes formation and atrophy of SG.
Keyphrases
  • wound healing
  • extracellular matrix
  • tissue engineering
  • soft tissue
  • mass spectrometry