The PhysioVP-AF study, a randomized controlled trial to assess the clinical benefit of physiological ventricular pacing vs. managed ventricular pacing for persistent atrial fibrillation prevention in patients with prolonged atrioventricular conduction: design and rationale.
Gianni PastoreMatteo BertiniCarlo BonannoGiovanni ColucciaGabriele Dell'EraLuca De MattiaDomenico GriecoGrigorius KatsourasMassimiliano MainesLina MarcantoniLeonardo MarinaccioGabriele PaglinoPietro PalmisanoMatteo ZiacchiFranco ZoppoFranco NoventaPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
The PhysioVP-AF study will provide an essential contribution to patient management with prolonged AV conduction and PM indication for sinus nodal disease or paroxysmal 2nd-degree AV-block by determining whether CSP combined with a controlled PR interval is superior to standard management that minimizes unnecessary VP in terms of reducing clinical outcomes.