Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischemic injury: a translational study.
Samuele AmbrosiniFabrizio MontecuccoDetmar KolijnDaniela PedicinoAlexander AkhmedovShafeeq A MohammedMelissa HerwigEra GoricaPetra Lujza SzabóLukas WeberGiulio RussoRamona VinciChristian M MatterGiovanna LiuzzoPeter J BrownFabio M V RossiGiovanni G CamiciSebastiano SciarrettaAntonio Paolo BeltramiThomas F LüscherBruno PodesserThomas F LüscherAttila KissFrank RuschitzkaNazha HamdaniSarah CostantinoFrancesco PaneniPublished in: Cardiovascular research (2022)
We show a methylation-dependent checkpoint regulating oxidative stress during myocardial ischemia. SETD7 inhibition may represent a valid therapeutic strategy in this setting.