A Prospective cohort study of zoonotic cutaneous leishmaniasis in tunisia: Clinical and Immunological features and immune correlates of protection.
Ikbel NaouarWafa Kammoun-RebaiAfif Ben SalahHind BouguerraAmine ToumiNabil Belhadj HamidaHechmi LouzirAmel Meddeb-GarnaouiPublished in: PLoS neglected tropical diseases (2023)
This study on a large cohort at risk of ZCL confirmed IFN-γ and GrB as protective factors against the disease. A high IFN-γ/IL-10 ratio, but not GrB/IL-10 ratio was associated with resistance. These results are valuable for developing and evaluating of a vaccine against human leishmaniasis.