Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors.

Alyxzandria M GaydosikTracy TabibLarisa J GeskinClaire-Audrey BayanJames F ConwayRobert A LafyatisPatrizia Fuschiotti

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Single-cell analysis of CTCL skin tumor samples reveals patient-specific landscapes of malignant and reactive lymphocytes within the local microenvironment of each tumor, giving an unprecedented view of lymphocyte heterogeneity and identifying tumor-specific molecular signatures, with important implications for diagnosis and personalized disease treatment.

Keyphrases

single cell
rna seq
peripheral blood
stem cells
soft tissue
wound healing
single molecule
combination therapy