Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses.

Trong Dao Nguyen Masaru IshibashiAdya Saran SinhaMiho WatanabeDaisuke KatoHiroshi HoriuchiHiroaki WakeAtsuo Fukuda

Published in: Epilepsia (2023)

Astrocytic NKCC1 inhibits GABA-mediated excitatory action during seizures, whereas neuronal NKCC1 has the converse effect, suggesting opposing actions of bumetanide on these cells.

Keyphrases

induced apoptosis
cell cycle arrest
cell proliferation
pi k akt