HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway.

Shalini SwaroopAnita MahadevanSusarla Krishna ShankarYogita K AdlakhaAnirban Basu

Published in: Journal of neuroinflammation (2018)

HSP60 mediates microglial IL-1β production by regulating NLRP3 inflammasome pathway and reduction of HSP60 leads to reduction of inflammation in JEV infection.

Keyphrases

nlrp inflammasome
heat shock protein
heat shock
heat stress
inflammatory response
oxidative stress
neuropathic pain
lps induced
spinal cord