Plasma CD27, a Surrogate of the Intratumoral CD27-CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma.
Nadine BenhamoudaIkuan SamNicolas EpaillardAlain GeyLetuan PhanHang-Phuong PhamNadège GruelAntonin SaldmanJoséphine PineauMilena HasanValentin QuiniouCamille NevoretVirginie VerkarreValentina LibriSébastien MellaClémence GranierChloe BroudinPatrice RavelEléonore De GuillebonLaetitia MaugeDominique HelleyBernd JaglaNathalie ChaputLaurence AlbigesSandrine KatsahianJulien AdamArnaud MejeanOlivier AdotéviYann-Alexandre VanoStephane Marie OudardEric TartourPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
In conclusion, we demonstrated that sCD27, a surrogate marker of T-cell dysfunction, is a predictive biomarker of resistance to immunotherapy in RCC. Given the frequent expression of CD70 and CD27 in solid tumors, our findings may be extended to other tumors.