Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles.
Xiaolei HuangMinh Hieu NguyenMaoping PuLuoqiang ZhangYonggui Robin ChiYun-Dong WuJianrong Steve ZhouPublished in: Angewandte Chemie (International ed. in English) (2020)
Conformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can be trapped by silanes and terminal alkynes.
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