The discovery and development of RNA-based therapies for treatment of HIV-1 infection.
Michelle J ChenAnne GatignolRobert J ScarboroughPublished in: Expert opinion on drug discovery (2022)
RNA-based technologies are among the top candidates for gene therapies where they can be stably expressed for long-term suppression of HIV-1. Advances in both gene and drug delivery strategies and improvements to non-coding RNA stability and antiviral properties will cooperatively drive forward progress in improving drug therapy and engineering HIV-1 resistant cells.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- drug delivery
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- induced apoptosis
- copy number
- genome wide
- men who have sex with men
- small molecule
- nucleic acid
- genome wide identification
- cell cycle arrest
- stem cells
- endoplasmic reticulum stress
- replacement therapy
- dna methylation
- cell proliferation
- transcription factor
- smoking cessation
- bone marrow