Mechanosensitive molecular mechanisms of myocardial fibrosis in living myocardial slices.

Raquel Nunez-ToldraThomas KirwinElisa FerraroFotios G PitoulisLaura NicastroIfigeneia BardiWorrapong Kit-AnanJulia GorelikAndre R SimonCesare M Terracciano

Published in: ESC heart failure (2022)

The LMS have a consistent fibrotic remodelling response to pathological load, which can be modulated by a TGF-βR blocker. The LMS platform allows the study of mechanosensitive molecular mechanisms of myocardial fibrosis and can lead to the development of novel therapeutic strategies.

Keyphrases

left ventricular
systemic sclerosis
transforming growth factor
idiopathic pulmonary fibrosis
liver fibrosis
atrial fibrillation
single cell