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BRCA mutation screening and patterns among high-risk Lebanese subjects.

Chantal FarraChristelle DagherRebecca BadraMiza Salim HammoudRaafat AlameddineJohnny AwwadMuhieddine SeoudJaber AbbasFouad BoulosNagi El SaghirDeborah A Mukherji
Published in: Hereditary cancer in clinical practice (2019)
The BRCA1 c.131G > T mutation can be considered a founder mutation in the Lebanese population detected among 5/17 (29%) of individuals diagnosed with a mutation in BRCA1 and among 7/269 families in this cohort. On review of recently published data regarding the landscape of BRCA mutations in the Middle East and North Africa, each region appears to have a unique spectrum of mutations.
Keyphrases
  • breast cancer risk
  • big data
  • machine learning
  • single cell
  • electronic health record
  • tertiary care
  • meta analyses