Charge-Tagged DNA Radicals in the Gas Phase Characterized by UV/Vis Photodissociation Action Spectroscopy.
Yue LiuAndy DangJan UrbanFrantišek TurečekPublished in: Angewandte Chemie (International ed. in English) (2020)
Adenosine radicals tagged with a fixed-charge group were generated in the gas phase and structurally characterized by tandem mass spectrometry, deuterium labeling, and UV/Vis action spectroscopy. Experimental results in combination with Born-Oppenheimer molecular dynamics, ab initio, and excited-state calculations led to unambiguous assignment of adenosine radicals as N-7 hydrogen atom adducts. The charge-tagged radicals were found to be electronically equivalent to natural DNA nucleoside radicals.
Keyphrases
- molecular dynamics
- single molecule
- tandem mass spectrometry
- density functional theory
- high resolution
- circulating tumor
- ultra high performance liquid chromatography
- high performance liquid chromatography
- liquid chromatography
- cell free
- solar cells
- simultaneous determination
- molecular dynamics simulations
- gestational age
- solid state
- ms ms
- low birth weight
- preterm infants
- circulating tumor cells
- preterm birth
- electron transfer