Angiotensin Receptor-Neprilysin Inhibitor Suppresses Renin-Angiotensin-Aldosterone System Activation After Cardiac Surgery Using Cardiopulmonary Bypass.

Joji HoshinoShunsuke SaitoIkuko ShibasakiToshimi SairenchiShohei OkuboTaiki MatsuokaShotaro HirotaShohei YokoyamaYuta KanazawaMasahiro TezukaYusuke TakeiGo TsuchiyaTaisuke KonishiKoji OgataHirotsugu Fukuda

Published in: Circulation journal : official journal of the Japanese Circulation Society (2024)

Sacubitril/valsartan administration was safe immediately after open heart surgery in patients without postoperative hypotension. It enhanced serum atrial natriuretic peptide concentrations and suppressed RAAS activation.

Keyphrases

ejection fraction
minimally invasive
angiotensin ii
angiotensin converting enzyme
end stage renal disease
newly diagnosed
atrial fibrillation
prognostic factors
patients undergoing
heart failure
signaling pathway
coronary artery disease
surgical site infection