Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

Till KaltofenValentina PreinfalkStephanie SchwertlerPatricia FraungruberHelene HeideggerTheresa VilsmaierAurelia VattaiBastian CzogallaDoris MayrSven MahnerUdo JeschkeFabian Trillsch

Published in: Journal of cancer research and clinical oncology (2020)

According to the described effects on EOC biology, all three Wnt manipulators seem to have the potential to augment the impact of a platinum-based chemotherapy in EOC. This is promising as a dominance of this pathway was confirmed in serous histology.

Keyphrases

high grade
stem cells
small molecule
cell proliferation
locally advanced
risk assessment
replacement therapy