T helper 17 cells: A new actor on the stage of type 2 diabetes and aging?

Yi-Cheng ChangSiow-Wey HeeLee-Ming Chuang

Published in: Journal of diabetes investigation (2021)

Metformin improves mitochondrial function and enhances autophagy of T helper 17 cells, leading to decreased inflammation. This highlights the importance of metabolic modulation of immune cells.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
cell death
regulatory t cells
signaling pathway